This masterful play examines the subtle and often perilous relationship between three remarkable women: The grandmother, Dorothea, who has sought to assert her independence through strong-willed eccentricity; her brilliant daughter, Artie (Artemis), who has fled the stifling domination of her mother; and Artie’s daughter, Echo, a child of exceptional intellect-and sensitivity-whom Artie has abandoned to an upbringing by Dorothea.